James Reilly, Kathleen Lynch and Alex White are predicted to lose their seats after the first full tallies of the count.
Renua leader Lucinda Creighton and Fianna Fáil Minister Mary Hanafin are also in trouble based on the predictions
The exit polls had shown the coalition only getting the support of about one third of the electorate and major seat losses imminent.
In Dublin West - home of Tánaiste and Labour leader Joan Burton - she's in a battle for a seat but is picking up significant transfers and many believe she'll be safe. Again Fianna Fáil will make a gain here.
In Dublin Fingal Fine Gael's Deputy leader James Reilly is in big big trouble and may be the party's biggest casualty and lose his seat.
Check out: GE16 live blog: The count
It's a little different for the party in Dun Laoghaire where Fine Gael looks set to take two of the three seats on offer - and stop the return of former Fianna Fáil Minister Mary Hanafin.
And in Dublin Bay South Fine Gael may be on the brink of ultimate revenge against Renua Leader Lucina Creighton and stop her holding a seat.
Other big names that could be gone after the counts - Labour's Alex White and Kathleen Lynch.
According to tallies, Fianna Fáil is topping the poll in Cork North Cental with Billy Kelleher capturing almost 28% of first preference votes.
With all 130 boxes tallied, Anti Austerity candidate Mick Barry is on a very respectable 15.8%. Sinn Fein's Jonathan O'Brien, poll-topper in Cork North Central last time out, has 12% of first preference votes followed by Fine Gael's Dara Murphy on just over 10%.
Billy Kelleher will be elected on the first count with Mick Barry likely to get in on the second count.
Also polling very well is Fine Gael's Julie O'Leary, on 7.5%, ahead of Labour's Kathleen Lynch on 7.35%. O'Leary's strong showing will ensure a Fine Gael seat in the four-seat constituency.
Thomas Gould of Sinn Fein polled 7.42% of first preference votes, also ahead of Kathleen Lynch.
The overall Sinn Fein vote will ensure the party takes a seat, meaning an almost inevitable loss of a seat for Minister Lynch.
