Detectives in the North have seized high purity cocaine with a large quantity of benzocaine.
The cocaine has a minimum street value of £60,000.
Two males aged 25 and 30 are being questioned at Musgrave Police Station as part of a joint operation between PSNI and An Garda Siochana National Drugs Unit.
A 20-year-old woman and a 37-year-old man have been released on Police bail.