Tommy O'Donnell comes in at openside flanker in place of Josh van der Flier in the only change in Joe Schmidt’s Ireland team for the Six Nations clash with Scotland.
Van der Flier misses out on the matchday squad altogether.
Rory Best has shrugged off a calf complaint to take his place in an otherwise unchanged line-up to the side that beat Italy last Saturday.
Cian Healy Healy, Eoin Reddan and Richardt Strauss are among the replacements, with Finlay Bealham, Kieran Marmion and Seán Cronin missing out.
Ireland: Zebo, Trimble, Payne, Henshaw, Earls, Sexton, Murray; McGrath, Best, Ross, Ryan, Toner, Stander, O’Donnell, Heaslip. Replacements: Strauss, Healy, White, Dillane, Ruddock, Reddan, Madigan, McFadden.
"Josh has shipped a couple of knocks in the last two games, and he got a bump in training on Monday," said Schmidt.
"I think they’ve been pretty attritional for Josh going back-to-back in his first two Test matches. He would be fit to play but at the same time is carrying a few knocks.
"Conversely Tommy has trained incredibly well. He hasn’t had the luckiest of preparations with us in previous times.
"And we’re looking forward to contributing a really athletic, combative performance this weekend."
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